| ncRNA name | AKR1B3 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Mus musculus |
| Tissues/Cell_line | mouse retinal microglia; murine macrophage-like RAW264.7 cells |
| Methods | siRNA transfection, immunofluorescence, Western blot, ELISA, transwell assay, Gelatin zymography |
| Expression pattern | associated |
| Functional description | Aldose reductase inhibition or genetic deficiency substantially reduced lipopolysacharide (LPS)-induced cytokine secretion from macrophages and RMG. Aldose reductase inhibition or deficiency also reduced the activation of MMP-9 and attenuated LPS-induced cell migration. |
| PubMed ID | 24677107 |
| Year | 2014 |
| Title | Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia. |
| Drug-related ncRNA | NO |
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